Tacrolimus toxicity following topical treatment of perianal Crohn's disease: An admonitory anecdote
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چکیده
منابع مشابه
Tacrolimus toxicity following topical treatment of perianal Crohn's disease: an admonitory anecdote.
A 23 year old female with a 12 year history of Crohn's disease had received a variety of systemic and biologic therapies, all of which were either of poor efficacy or had been poorly tolerated. Most recently an end ileostomy and rectal stump had been formed, with a view to ileal pouch formation at a later date. However, our patient continued to develop deep ulceration of the anal verge and dist...
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A 32-year-old man, who was undergoing treatment for eyelid dermatitis with topical tacrolimus ointment 0.1% (0.5 g applied twice daily for 1 wk), presented with periorbital erythema accompanied by a mild burning sensation that developed 30 minutes after he ingested one alcoholic beverage (Figure 1). The eruption was limited to the application site and resolved within one to two hours. Tacrolimu...
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Dr. Antonio Ledo, Castellana 167, E-28046 Madrid (Spain) In 1966 Amren et al. [1] reported 10 cases of perianal erythema caused by group A ß-hemolytic streptococci. Usually it is observed in prepuberal males and is characterized by well-demarcated perianal erythema without satellite lesions. Occasionally patients have fissures, painful defecation with secondary constipation and rectal bleeding....
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Atopic dermatitis (AD) is a common, chronic, relapsing, severely pruritic, eczematous skin disease. The mainstays of treatment for AD are topical tacrolimus and topical steroids. Tacrolimus, a calcineurin inhibitor, not only complements existing treatment options but also overcomes some of the drawbacks of topical steroid therapy when given topically and thus meets the long-term needs of patien...
متن کاملTopical tacrolimus for recurrent penile Crohn's disease.
Skin lesions are associated with Crohns disease (CD) in 22– 44% of patients. Metastatic Crohn's disease (MCD) is defined as granulomatous skin lesions occurring at sites separate from the gastrointestinal tract, mainly in the lower extremities and intertriginous areas.1 Genital MCD has been frequently described as refractory and usually begins as a non-healing ulcer, but can be shown as a papul...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2013
ISSN: 1873-9946
DOI: 10.1016/j.crohns.2013.08.013